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Therefore, it was felt that an article such as this was needed.

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While knowledge of the mechanisms underlying chronic craniofacial pain remains limited, both clinical and preclinical investigations suggest that changes in afferent inputs to the brain as well as in brain structure and modulatory pathways occur in chronic pain.

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Simple pains may be treated with ease; however, chronic pain is a different matter.

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Ann Acad Med Singapore.

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Preclinical studies have provided substantial information about the anatomical and physiological mechanisms related to the initiation and modulation of nociceptive signals in the trigeminal system.

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Many concepts presented within are either new or revised.

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The purpose of this article is primarily one of education.

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Ann Acad Med Singapore.

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Undiagnosed pain in the face, head and neck is very frustrating to all parties involved:

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